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In vitro study demonstrates human intestine-type CES expression and preserved barrier integrity in engineered Caco-2 cells, highlighting their potential for ester-containing drug permeability tests.
cells carry the human intestinal-type CES expression profile, while concomitantly retaining their barrier properties, it can be expected that this cell line will provide a promising in vitro model for ester-containing drug permeability studies.
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Ishizaki et al. (2018) studied this question.
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