), remodelling and angiogenesis after 16 weeks, enabling the Mg fibres to facilitate complete tissue healing and provide sufficient mechanical strength (3.32 ± 0.92 MPa and 152 ± 1 MPa for apparent yield stress and Young's modulus, respectively) to support loading. This study suggests that Mg-based fibres can promote osteointegration and osteoconduction enabling the reconstruction of critical-sized defects while maintaining the mechanical integrity of the injured site. STATEMENT OF SIGNIFICANCE: Magnesium is a highly promising biomaterial for bone regeneration; however, its rapid corrosion in physiological environments can compromise mechanical integrity and lead to treatment failure. This study investigates an innovative strategy designed to slow corrosion, combining 1) a magnesium alloy without aluminium, neodymium or gadolinium, elements commonly present in AZ31 or WE24 alloys but associated with poor biocompatibility and 2) a fluorine coating. The biological and mechanical performance of this composite biomaterial were assessed after implantation in a critical-size bone defect, using histological analyses, X‑ray computed tomography, and digital volume correlation to evaluate bone healing. The findings will contribute to the advancement of safe and effective biomaterials that can be translated to clinical solutions for bone tissue regeneration.
Bonithon et al. (2026) studied this question.