Insights of traditional Indian anti-aging herbal beverages, network pharmacology, and perspectives.

Plants have served as important sources of medicine since prehistoric times, forging a strong connection between humans and their environment. This relationship has yielded valuable insights into the therapeutic use of herbs for various health conditions. The current study aims to gather scientific evidence about traditional Indian anti-aging herbal beverages that have been practiced for centuries. We conducted a literature search through online databases, research articles, search engines, and books, covering the period from 2000 to February 2025. We examined 1,221 articles and selected 53 from 298 for the most relevant information. The secondary metabolites of these traditional beverages interact with key biological functions and develop polarization with the ability to combat bacteria, reduce inflammation, eliminate harmful reactive oxygen species (ROS), and influence aging. Ascorbic acid, kempferol, quercetin, β-carotene, and chlorogenic acid were found in three or more beverages we screened in the present investigation. These beverages contribute to cell functions, lower oxidative stress, prevent chronic diseases, and reduce inflammation. The strong therapeutic potential of these beverages, combined with their low toxicity, has led to widespread public acceptance and highlighted the need for further research. Although certain beverages share common ingredients, understanding their functional molecular mechanisms is limited. Network pharmacological studies have identified a module of 22 nodes linked to the anti-aging effects of these beverages. Additionally, clinical trials may help create new food supplements and modern green medicines.