Evaluating the effects of A-803467, a selective NaV1.8 blocker, on cough response in guinea pigs with allergic rhinitis.

Key Points

• This research aims to evaluate the effectiveness of A-803467 in reducing cough responses in guinea pigs with allergic rhinitis.
• Guinea pigs were pretreated with aerosolized A-803467 (3mM) or vehicle for 10 min prior to citric acid exposure.
• Animals were subjected to OVA (ovalbumin) challenge to induce allergic rhinitis.
• Cough responses were measured after treatment during exposure to the irritant.
• A-803467 significantly reduced cough responses in treated animals compared to the vehicle group.
• No significant change in respiratory rate was observed during the treatments.
• Findings suggest nav1.8 as a potential therapeutic target for managing cough in allergic airway inflammation.