Population
Sensitized, perfused guinea pig lung model
Comparison
Bilateral vagal stimulation combined with… vs Vagal stimulation alone or aerosolized antigen…
Design
Preclinical
Authors
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NK-2 blockade attenuates vagal-antigen synergy in guinea pigs; hypothesis-generating for NK-2 antagonists in human anaphylaxis.
Vagally mediated potentiation of pulmonary anaphylaxis in guinea pigs is predominantly driven by NK-2 receptors and associated with elevated eicosanoids and histamine.
Tocker et al. (1995) studied this question.
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