Answers are grounded in this paper and cite their sources.
Examines bronchial response to antigen in guinea-pigs, suggesting sensitization methods impact outcomes.
This work studies the temporal development of the acute anaphylactic bronchoconstriction in guinea-pigs sensitized to ovalbumin by different regimens, including IgE-antibody promoting ones. The results show that guinea-pigs sensitized with low amounts (1-10 micrograms) of ovalbumin together with alum produce the most pronounced bronchospasm when challenged with an intravenous injection of a low dose of antigen. Examination of the antibody classes by PCA technique shows that guinea-pigs sensitized with small amounts of antigen together with alum produced IgE and IgG1 antibodies. However, in sera from animals immunized with large amounts of antigen, only IgG1 antibodies could be detected.
No takes yet. Share an insight, caveat, or question.
Per Andersson (1980) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: