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July 1, 1988British Journal of PharmacologyOpen Access

The effect of ozone on reactivity of upper and lower airways in guinea‐pigs

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Why the study?

Does ozone inhalation increase airway reactivity to histamine in guinea-pigs?

Population

Conscious guinea-pigs

Comparison

Ozone inhalation (3.5 p.p.m. for 30 min) vs Control (unexposed or baseline)

Design

Preclinical

Authors

MHM.C. HolroydeUniversity of GuelphANA.A. NorrisUniversity of Liverpool

Discussion

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Overview

Should not change clinical ozone exposure guidance; leaves open human translation of lower airway hyperreactivity.

Structured PICO

Does ozone inhalation increase airway reactivity to histamine in guinea-pigs?

P
Population
Conscious guinea-pigs
I
Intervention
Ozone inhalation (3.5 p.p.m. for 30 min)
C
Comparator
Control (unexposed or baseline)
O
Outcome
Responsiveness of upper and lower airways to histaminesurrogate

Ozone exposure induces lower airway hyperreactivity to histamine in guinea-pigs through a mechanism independent of leukotriene generation or vagal reflex.

Cite This Study

Holroyde et al. (1988) studied this question.

synapsesocial.com/papers/6a20acbf920e38fa09f9e4d1https://doi.org/10.1111/j.1476-5381.1988.tb11607.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct and indirect actions of histamine on airway smooth muscle in guinea pigs1984 · 5 citations
  2. 2Ozone-induced bronchial hyperreactivity in guinea pigs is abolished by BW 755C or FPL 55712 but not by indomethacin.1985 · 45 citations
  3. 3Mechanics of Respiration in Unanesthetized Guinea Pigs1958 · 635 citations
  4. 4The effect of a respiratory tract infection on histamine-induced changes in lung mechanics and irritant receptor discharge in dogs.1979 · 25 citations