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June 1, 1979Journal of Applied Physiology

Mechanism of rapid, shallow breathing after ozone exposure in conscious dogs

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Population

3 conscious dogs exercising on a treadmill (10 experiments)

Comparison

Ozone exposure with and without vagal cooling vs Baseline (prior to ozone exposure)

Design

Preclinical

Follow-up

2 hours

Authors

LLL. Y. LeeCDC DumontGalapagos (France)TDT. D. DjokicUniversity of California, San Francisco

Discussion

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Overview

Vagal mediation of ozone-induced rapid shallow breathing confirmed in dogs; leaves open human applicability and clinical translation.

Structured PICO

P
Population
3 conscious dogs exercising on a treadmill (10 experiments)
I
Intervention
Ozone exposure (0.65 ppm for 2 h) with and without vagal cooling
C
Comparator
Baseline (prior to ozone exposure)
O
Outcome
Changes in base-line ventilation (respiratory frequency and tidal volume)surrogate

Ozone-induced rapid, shallow breathing and increased ventilatory responses to bronchoconstrictors are mediated through vagal afferent pathways in conscious dogs.

Cite This Study

Lee et al. (1979) studied this question.

synapsesocial.com/papers/6a1fc9d82be0c1f4e3bb43e4https://doi.org/10.1152/jappl.1979.46.6.1108
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contribution of vagal afferents to respiratory reflexes evoked by acute inhalation of ozone in dogs1993 · 52 citations
  2. 2Time course of ozone-induced changes in breathing pattern in healthy exercising humans2006 · 23 citations
  3. 3Ozone enhances excitabilities of pulmonary C fibers to chemical and mechanical stimuli in anesthetized rats1998 · 60 citations
  4. 4Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects2015 · 97 citations
  5. 5The effect of ozone on reactivity of upper and lower airways in guinea‐pigs1988 · 29 citations