Key result
Ozone exposure induced a three-phase breathing response where the cumulative inhaled dose at onset of tachypnea remained constant, and indomethacin attenuated the percent change in breathing frequency.
Why the study?
What is the time course and mechanism of ozone-induced changes in breathing patterns in healthy exercising humans?
Population
97 healthy human subjects (70 men and 27 women) undergoing exercise
Comparison
Ozone exposure with varying concentrations… vs Varying ozone concentrations, ventilation rates…
Design
Other
Authors
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Hypothesis-generating for cumulative ozone dose thresholds in exercise; leaves open clinical translation and exposure guidelines.
What is the time course and mechanism of ozone-induced changes in breathing patterns in healthy exercising humans?
Ozone-induced tachypnea onset depends on a constant cumulative inhaled dose of ozone, and the magnitude of the response is partially mediated by cyclooxygenase pathways as shown by indomethacin attenuation.
Schelegle et al. (2006) studied Healthy (n=97). Ozone (O3) exposure was evaluated on Time course of O3-induced changes in breathing pattern (time to onset, number of breaths at onset, cumulative inhaled dose of ozone, and percent change in breathing frequency). Ozone exposure induced a three-phase breathing response where the cumulative inhaled dose at onset of tachypnea remained constant, and indomethacin attenuated the percent change in breathing frequency.
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