Key result
Acute exposure to ozone significantly enhanced the stimulatory effect of capsaicin on pulmonary C fibers in rats (6.05 vs 0.77 impulses/s; P<0.01).
Population
31 C fibers in anesthetized, open-chest, and vagotomized rats
Comparison
Acute exposure to ozone at 3 parts/million for… vs Control state prior to O3 exposure
Design
Preclinical
Authors
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May contribute to ozone-induced respiratory symptoms; leaves open human translation and clinical relevance.
Absolute Event Rate: 6.05% vs 0.77%
p-value: p=<0.01
Acute ozone exposure potentiates the excitability of pulmonary C-fiber afferents to chemical and mechanical stimuli in rats, which may explain ozone-induced breathing changes and chest discomfort.
Ho et al. (1998) studied this question. Acute exposure to ozone (O3) vs. Control (pre-exposure) was evaluated on C-fiber response to capsaicin (impulses/s) (p=<0.01). Acute exposure to ozone significantly enhanced the stimulatory effect of capsaicin on pulmonary C fibers in rats (6.05 vs 0.77 impulses/s; P<0.01).
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