Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1995Journal of Applied Physiology

Pulmonary chemoreflex sensitivity is enhanced by prostaglandin E2 in anesthetized rats

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does prostaglandin E2 enhance the pulmonary chemoreflex sensitivity to capsaicin or phenyl biguanide in anesthetized rats?

Population

Anesthetized Sprague-Dawley rats

Comparison

Prostaglandin E2 constant infusion combined with… vs Capsaicin or phenyl biguanide alone

Design

Preclinical

Authors

LLLu‐Yuan LeeUnited States Department of Veterans AffairsRMR. F. MortonSaint Louis University

Discussion

Loading...

Member takes

Overview

PGE2 sensitizes pulmonary C-fiber reflexes in rats; leaves open relevance to human cardiopulmonary disease.

Structured PICO

Does prostaglandin E2 enhance the pulmonary chemoreflex sensitivity to capsaicin or phenyl biguanide in anesthetized rats?

P
Population
Anesthetized Sprague-Dawley rats
I
Intervention
Prostaglandin E2 (PGE2) constant infusion (1.5 micrograms.kg-1.min-1 i.v.) combined with capsaicin (0.25 or 0.5 microgram/kg i.v.) or phenyl biguanide (1 or 2 micrograms/kg i.v.)
C
Comparator
Capsaicin or phenyl biguanide alone (without PGE2 infusion)
O
Outcome
Pulmonary chemoreflex response (apnea, bradycardia, and hypotension) and pulmonary C-fiber afferent activitysurrogate

Prostaglandin E2 significantly enhances the sensitivity of pulmonary C-fiber afferents and the resulting pulmonary chemoreflex in anesthetized rats.

Cite This Study

Lee et al. (1995) studied this question.

synapsesocial.com/papers/6a896004b4e829b19bd4446ahttps://doi.org/10.1152/jappl.1995.79.5.1679
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sensitivity of the Human Cough Reflex: Effect of Inflammatory Mediators Prostaglandin E2, Bradykinin, and Histamine1989 · 235 citations
  2. 2Attenuation of the pulmonary chemoreflex following acute cervical spinal cord injury2014 · 15 citations
  3. 3Rapid shallow breathing evoked by capsaicin from isolated pulmonary circulation1986 · 15 citations
  4. 4Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats2018 · 17 citations
  5. 5Acute effects of intravenous capsaicin on breathing rate, heart rate and blood gases in anesthetized mice with and without atropine and mechanical ventilation2026