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February 21, 2014Journal of Applied Physiology

Attenuation of the pulmonary chemoreflex following acute cervical spinal cord injury

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Why the study?

Does acute cervical spinal cord injury attenuate the pulmonary chemoreflex induced by bronchopulmonary C-fiber activation in rats?

Population

Adult male Sprague-Dawley rats

Comparison

Unilateral hemisection in the second cervical… vs Laminectomy followed by intrajugular capsaicin…

Design

Preclinical

Follow-up

acute

Authors

ITI‐Lun TsaiNational Sun Yat-sen UniversityKLKun‐Ze LeeNational Sun Yat-sen University

Discussion

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Overview

Attenuated chemoreflex post-C2Hx in rats; leaves open whether compensatory plasticity occurs in human cervical SCI.

Structured PICO

Does acute cervical spinal cord injury attenuate the pulmonary chemoreflex induced by bronchopulmonary C-fiber activation in rats?

P
Population
Adult male Sprague-Dawley rats
I
Intervention
Unilateral hemisection (Hx) in the second cervical spinal cord (C2Hx) followed by intrajugular capsaicin or phenylbiguanide administration
C
Comparator
Laminectomy (uninjured) followed by intrajugular capsaicin or phenylbiguanide administration
O
Outcome
Pulmonary chemoreflex evaluated by measuring respiratory airflow in spontaneously breathing rats and phrenic nerve activity in mechanically ventilated ratssurrogate

Acute cervical spinal cord injury attenuates the pulmonary chemoreflex induced by bronchopulmonary C-fiber activation, suggesting a compensatory respiratory plasticity.

Cite This Study

Tsai et al. (2014) studied this question.

synapsesocial.com/papers/6a927371cfe2d75514a5eeb5https://doi.org/10.1152/japplphysiol.01370.2013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulation of vagal pulmonary C-fibers by a single breath of cigarette smoke in dogs1989 · 110 citations
  2. 2Respiratory motor outputs following unilateral midcervical spinal cord injury in the adult rat2013 · 42 citations
  3. 3Pulmonary C-fiber activation attenuates respiratory-related tongue movements2012 · 15 citations
  4. 4Acute effects of cigarette smoke on breathing in rats: vagal and nonvagal mechanisms1990 · 34 citations
  5. 5Neural drive to tongue protrudor and retractor muscles following pulmonary C-fiber activation2006 · 18 citations