November 1, 1998Journal of Applied Physiology

Nociceptive mechanisms modulate ozone-induced human lung function decrements

View Full Paper

Ask AI

Bookmark

Why the study?

Do opioid-receptor agonists reverse ozone-induced chest pain and lung function decrements in healthy volunteers?

Population

62 healthy volunteers (18-59 yr) known to be 'weak' (WR; n = 20) and 'strong' ozone responders (SR; n = 42).

Comparison

Naloxone for weak responders, or sufentanil for… vs Saline iv.

Design

RCT, Randomly assigned to intervention or saline., Double-blind

Follow-up

Immediate post-exposure

Authors

APAnthony N. PassannanteUniversity of North Carolina at Chapel Hill MHMilan J. HazuchaUniversity of North Carolina at Chapel Hill PBPhilip A. BrombergUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Rapid reversal supports opioid agonists for irritant exposures; confirms nociceptive mechanisms in ozone-induced inspiratory inhibition.

Structured PICO

Do opioid-receptor agonists reverse ozone-induced chest pain and lung function decrements in healthy volunteers?

Population

62 healthy volunteers (18-59 yr) known to be 'weak' (WR; n = 20) and 'strong' ozone responders (SR; n = 42).

Intervention

Naloxone (0.15 mg/kg iv) for weak responders, or sufentanil (0.2 microgram/kg iv) for strong responders, administered immediately after post-ozone spirometry.

Comparator

Saline iv.

Outcome

Reversal of ozone-induced chest pain and spirometric effects (forced expiratory volume in 1 s).surrogate

Nociceptive mechanisms play a key role in modulating ozone-induced inhibition of inspiration in strong responders.

Cite This Study

Passannante et al. (1998) studied this question.

synapsesocial.com/papers/6a7d778af71d7d96a037cc88 https://doi.org/10.1152/jappl.1998.85.5.1863

View Full Paper

Ask AI

Bookmark

November 1, 1998Journal of Applied Physiology

Nociceptive mechanisms modulate ozone-induced human lung function decrements

View Full Paper

Ask AI

Bookmark

Why the study?

Do opioid-receptor agonists reverse ozone-induced chest pain and lung function decrements in healthy volunteers?

Population

62 healthy volunteers (18-59 yr) known to be 'weak' (WR; n = 20) and 'strong' ozone responders (SR; n = 42).

Comparison

Naloxone for weak responders, or sufentanil for… vs Saline iv.

Design

RCT, Randomly assigned to intervention or saline., Double-blind

Follow-up

Immediate post-exposure

Authors

APAnthony N. PassannanteUniversity of North Carolina at Chapel Hill MHMilan J. HazuchaUniversity of North Carolina at Chapel Hill PBPhilip A. BrombergUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Rapid reversal supports opioid agonists for irritant exposures; confirms nociceptive mechanisms in ozone-induced inspiratory inhibition.

Structured PICO

Do opioid-receptor agonists reverse ozone-induced chest pain and lung function decrements in healthy volunteers?

Population

62 healthy volunteers (18-59 yr) known to be 'weak' (WR; n = 20) and 'strong' ozone responders (SR; n = 42).

Intervention

Naloxone (0.15 mg/kg iv) for weak responders, or sufentanil (0.2 microgram/kg iv) for strong responders, administered immediately after post-ozone spirometry.

Comparator

Saline iv.

Outcome

Reversal of ozone-induced chest pain and spirometric effects (forced expiratory volume in 1 s).surrogate

Nociceptive mechanisms play a key role in modulating ozone-induced inhibition of inspiration in strong responders.

Cite This Study

Passannante et al. (1998) studied this question.

synapsesocial.com/papers/6a7d778af71d7d96a037cc88 https://doi.org/10.1152/jappl.1998.85.5.1863

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark