Why the study?
Does naloxone increase breathlessness during treadmill exercise in patients with chronic obstructive pulmonary disease?
Does naloxone increase breathlessness during treadmill exercise in patients with chronic obstructive pulmonary disease?
Endogenous opioids appear to modify dyspnoea during exercise in COPD patients by altering central perception, as evidenced by increased breathlessness when blocked by naloxone.
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Naloxone increases exertional breathlessness in COPD; confirms endogenous opioids attenuate dyspnoea perception.
Mahler et al. (2009) studied this question.
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