November 1, 1985Circulation
The nature of opioid involvement in the hemodynamic respiratory and humoral responses to exercise.
Key result
Naloxone infusion did not affect intra-arterial pressure, heart rate, ventilation, O2 uptake, CO2 output, or exercise performance during exhaustive graded exercise in healthy males.
Why the study?
Does naloxone alter the hemodynamic, respiratory, and humoral responses to exercise in healthy male volunteers?
Population
12 healthy male volunteers, average age 22 years
Comparison
Naloxone vs Saline
Design
RCT, randomized cross-over protocol, double-blind
Follow-up
duration of exercise experiment (short duration)
Authors
Discussion
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Implication
Naloxone does not modify exercise responses in healthy males; confirms endogenous opioids are uninvolved and narrows mechanistic research.
Key Points
- To evaluate whether endogenous opioids modulate hemodynamic, respiratory, and hormonal responses at rest and during exhaustive exercise.
- Conducted a randomized, double-blind, crossover trial in 12 healthy male volunteers (average age 22 years).
- Administered intravenous naloxone (10 mg bolus followed by 10 mg/hr infusion) or saline placebo during recumbent rest, seated rest, and bicycle ergometer exercise to exhaustion.
- During rest, naloxone infusion significantly increased plasma concentrations of ACTH, cortisol, and aldosterone while decreasing body temperature.
- During maximal exercise, differences in plasma ACTH between naloxone and saline disappeared, and differences in cortisol and aldosterone lost statistical significance.
- Naloxone produced no significant changes in intra-arterial blood pressure, heart rate, ventilation, oxygen uptake, carbon dioxide output, metabolic substrates, or total exercise performance.
Study Design
Type
RCT (n=12)
Blinding
Double-blind
Randomization
cross-over
Structured PICO
Does naloxone alter the hemodynamic, respiratory, and humoral responses to exercise in healthy male volunteers?
P
Population
12 healthy male volunteers, average age 22 years, undergoing exhaustive graded exercise.
I
Intervention
Naloxone (10 mg iv followed by a continuous infusion of 10 mg/hr)
C
Comparator
Saline
O
Outcome
Hemodynamic, respiratory, and humoral responses to exercise (including ACTH, cortisol, aldosterone, intra-arterial pressure, heart rate, ventilation, O2 uptake, CO2 output)surrogate
Endogenous opioids do not appear to be involved in the hemodynamic, respiratory, and hormonal responses to exhaustive graded exercise of short duration.
Cite This Study
Staessen et al. (1985) conducted an RCT in Healthy (n=12). Naloxone vs. Saline was evaluated on Hemodynamic, respiratory, and hormonal responses to exercise. Naloxone infusion did not affect intra-arterial pressure, heart rate, ventilation, O2 uptake, CO2 output, or exercise performance during exhaustive graded exercise in healthy males.