Why the study?
Does naloxone potentiate cardiopulmonary baroreflex sympathetic control in normal humans?
Population
21 normal subjects, mean age 24 +/- 1 years
Comparison
Naloxone administered on separate days vs Placebo or baseline (before naloxone)
Design
Other
Authors
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Should not alter clinical management; leaves open whether opioid antagonism benefits patients with baroreflex impairment.
Does naloxone potentiate cardiopulmonary baroreflex sympathetic control in normal humans?
Naloxone selectively potentiates cardiopulmonary baroreflex regulation of sympathetic neural activity, suggesting that endogenous opioids exert a tonic inhibitory effect on sympathetic responses to orthostatic stress in normal humans.
Schobel et al. (1992) studied this question.
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