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January 1, 1994Journal of the American College of CardiologyOpen Access

Short-term effects of naloxone hemodynamics and baroreflex function in conscious dogs with pacing-induced congestive heart failure

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Why the study?

Does naloxone improve systemic hemodynamics and baroreflex function in dogs with pacing-induced congestive heart failure?

Population

15 dogs with pacing-induced congestive heart failure (225 beats/min for 8 weeks) and 11 control dogs

Comparison

Naloxone (1 mg/kg body weight) vs Normal saline solution

Design

Preclinical

Follow-up

short-term

Authors

YHYoshihiro HimuraHikone Central HospitalCLChang‐seng LiangBoston UniversityNIN ImaiUniversity of Rochester Medical Center

Discussion

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Implication

Naloxone may improve hemodynamics in this canine HF model; extends right-sided data but leaves open human relevance.

Structured PICO

Does naloxone improve systemic hemodynamics and baroreflex function in dogs with pacing-induced congestive heart failure?

P
Population
15 dogs with pacing-induced congestive heart failure (225 beats/min for 8 weeks) and 11 control dogs
I
Intervention
Naloxone (1 mg/kg body weight)
C
Comparator
Normal saline solution
O
Outcome
Systemic hemodynamics, myocardial contractility (slope of pressure-area relation), and baroreflex function (slope of regression line relating systolic aortic pressure and RR interval)surrogate

Naloxone improves systemic hemodynamics and myocardial contractile function in dogs with pacing-induced left-sided congestive heart failure, suggesting endogenous opioids mediate myocardial depression in heart failure.

Cite This Study

Himura et al. (1994) studied this question.

synapsesocial.com/papers/6a1befaeea84844e355f31f2https://doi.org/10.1016/0735-1097(94)90520-7

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Naloxone in septic shock1990 · 43 citations
  2. 2Selective impairment of baroreflex-mediated vasoconstrictor responses in patients with ventricular dysfunction.1984 · 258 citations
  3. 3Influence of acute changes in preload, afterload, contractile state and heart rate on ejection and isovolumic indices of myocardial contractility in man.1976 · 340 citations
  4. 4Analysis of baroreflex control of heart rate in conscious dogs with pacing-induced heart failure.1991 · 59 citations
  5. 5Reduced baroreflex sensitivity with volume loading in conscious dogs.1975 · 120 citations