Why the study?
Does naloxone alter baroreceptor reflex sensitivity in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Naloxone (40 micrograms/kg) vs Baseline (before administration of naloxone)
Design
Preclinical
Authors
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No direct clinical implications from canine data; leaves open translational relevance of endogenous opioid modulation of baroreflex in humans.
Does naloxone alter baroreceptor reflex sensitivity in anesthetized dogs?
Endogenous opioids appear to modulate baroreflex function in dogs, as evidenced by naloxone significantly blunting baroreflex sensitivity.
Julianna E. Szilagyi (1987) studied this question.
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