Why the study?
Does naloxone reduce plasma renin activity and arterial blood pressure in dogs with partial renal arterial constriction?
Population
Unilaterally nephrectomized dogs with partial renal arterial constriction (acute and chronic preparations)
Comparison
Naloxone or morphine vs Saline vehicle
Design
Preclinical
Follow-up
15 minutes (acute) and long-term (chronic)
Authors
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Naloxone effects in dogs suggest opioid modulation of renin; hypothesis-generating for human renovascular hypertension, requiring clinical studies.
Does naloxone reduce plasma renin activity and arterial blood pressure in dogs with partial renal arterial constriction?
Endogenous opioid peptides appear to modulate renin release and may play a role in the pathogenesis of renovascular hypertension.
Szilagyi et al. (1986) studied this question.
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