August 1, 1990Hypertension

Cardiac afferents attenuate renal sympathetic baroreceptor reflexes during acute hypertension.

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Population

conscious rabbits

Comparison

Acute hypertensive episodes induced by… vs Baseline (before elevation in resting pressure)

Design

Preclinical

Authors

PDPatricia K. DorwardBaker Heart and Diabetes Institute LBL. B. BellMedical University of South Carolina CRCarl D. RuddRoyal Women's Hospital

Discussion

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Implication

May implicate cardiac afferents in hypertension-induced baroreflex impairment in rabbits; extends mechanistic insight but leaves open human relevance.

Structured PICO

Population

conscious rabbits

Intervention

Acute hypertensive episodes induced by methoxamine infusion (+30 and +45 mm Hg) in the presence of autonomic blockade (atenolol and methscopolamine), with subsequent blockade of cardiac afferents (5% intrapericardial procaine) or endogenous opiates (intravenous naloxone 4-6 mg/kg, then 0.12 mg/kg/min)

Comparator

Baseline (before elevation in resting pressure)

Outcome

Renal sympathetic baroreceptor reflex (measured via renal sympathetic nerve activity)surrogate

Acute hypertension attenuates the renal sympathetic baroreceptor reflex in conscious rabbits, with cardiac afferents mediating approximately one third of this sympathoinhibition.

Cite This Study

Dorward et al. (1990) studied this question.

synapsesocial.com/papers/6a7affafbdf697b3de02d8d3 https://doi.org/10.1161/01.hyp.16.2.131

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

May implicate cardiac afferents in hypertension-induced baroreflex impairment in rabbits; extends mechanistic insight but leaves open human relevance.

Cardiac afferents attenuate renal sympathetic baroreceptor reflexes during acute hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cardiac afferents attenuate renal sympathetic baroreceptor reflexes during acute hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

Also Consider