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January 1, 1995Journal of Cardiovascular PharmacologyOpen Access

Baroreflexes and Cardiovascular Regulation in Hypertension

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Population

Hypertensive humans and animal models (rats, conscious rabbits)

Design

Review

Authors

GHGeoffrey A. HeadPreventive Cardiology

Discussion

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Implication

Hypothesis-generating for baroreflex restoration in hypertension; prospective trials needed before clinical adoption.

Structured PICO

P
Population
Hypertensive humans and animal models (rats, conscious rabbits)
I
Intervention
Centrally acting antihypertensive agents (e.g., rilmenidine)
O
Outcome
Baroreflex control of heart rate and sympathetic vasomotor functionsurrogate

Centrally acting antihypertensive agents like rilmenidine improve baroreflex function by reducing sympathetic activity and increasing vagal sensitivity, which may beneficially reduce blood pressure variability in hypertension.

Cite This Study

Geoffrey A. Head (1995) studied this question.

synapsesocial.com/papers/6a832b4088eff2bd7befebfchttps://doi.org/10.1097/00005344-199506262-00002

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CARDIAC BAROREFLEXES AND HYPERTENSION1994 · 94 citations
  2. 2Role of the heart in blood pressure lowering during chronic baroreflex activation: insight from an in silico analysis2018 · 15 citations
  3. 3Cardiovascular reflexes and hypertension.1991 · 55 citations
  4. 4Baroreflex control of sympathetic activity in experimental hypertension1998 · 54 citations
  5. 5ANTIHYPERTENSIVE DRUGS AND BARORECEPTOR REFLEX CONTROL OF HEART RATE AND BLOOD PRESSURE1987 · 16 citations