What does this research mean for the field?

Inhibition of opiate receptors improves blunted baroreflex sensitivity in dogs with right-sided congestive heart failure, indicating that elevated endogenous opioids contribute to baroreflex dysfunction in heart failure. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1989CirculationOpen Access

Opiate receptor inhibition improves the blunted baroreflex function in conscious dogs with right-sided congestive heart failure.

View Full Paper

Ask AI

Bookmark

Why the study?

Does opiate receptor inhibition improve baroreflex function in conscious dogs with right-sided congestive heart failure?

Population

23 conscious dogs.

Comparison

Pretreatment with an opiate-receptor antagonist… vs Pretreatment with normal saline.

Design

Preclinical

Authors

SSSusumu SakamotoToho University CLChang‐seng LiangBoston University

Discussion

Member takes

Implication

Opioid antagonism may restore baroreflex sensitivity in experimental HF; leaves open translation to human heart failure.

Structured PICO

Does opiate receptor inhibition improve baroreflex function in conscious dogs with right-sided congestive heart failure?

Population

23 conscious dogs (16 with right-sided congestive heart failure produced by tricuspid avulsion and progressive pulmonary artery constriction, and 7 sham-operated dogs for comparison).

Intervention

Pretreatment with an opiate-receptor antagonist (naloxone hydrochloride, naloxonazine, ICI 154,129, or naloxone methobromide) prior to bolus administration of phenylephrine.

Comparator

Pretreatment with normal saline.

Outcome

Baroreflex sensitivity (slope of the regression line relating systolic blood pressure to cardiac cycle (R-R) interval).surrogate

Cite This Study

Sakamoto et al. (1989) studied this question.

synapsesocial.com/papers/6a19bb6b443d3ecd7cdef1dd https://doi.org/10.1161/01.cir.80.4.1010

Topics

Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

Opiate receptor inhibition improves the blunted baroreflex function in conscious dogs with right-sided congestive heart failure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Opiate receptor inhibition improves the blunted baroreflex function in conscious dogs with right-sided congestive heart failure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider