Why the study?
Does nalmefene alter systemic and regional hemodynamics in an experimental dog model of right-sided congestive heart failure?
Population
Dogs with experimental right-sided congestive heart failure produced by surgical tricuspid avulsion and…
Comparison
Nalmefene administered after pretreatment with… vs Sham-operated dogs and baseline measurements.
Design
Preclinical
Authors
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Should not change heart failure management; leaves open opioid antagonism as a research target for hemodynamic modulation.
Does nalmefene alter systemic and regional hemodynamics in an experimental dog model of right-sided congestive heart failure?
Endogenous opioids play a role in the hemodynamic alterations of congestive heart failure, as opiate receptor antagonism with nalmefene improves cardiac output and regional blood flow through interactions with the sympathetic nervous system.
Liang et al. (1987) studied this question.
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