November 1, 1990Journal of Cardiovascular Pharmacology
Pacing-Induced Heart Failure in the Dog: Evaluation of Peripheral Vascular α-Adrenoceptor Subtypes
Key result
Pacing-induced heart failure increases peripheral vascular sensitivity and reactivity to alpha 1-agonists.
Why the study?
Postjunctional alpha-adrenoceptor characteristics in peripheral vasculature during severe pacing-induced heart failure were not fully characterized.
Population
Canine dorsal pedal arterial and saphenous vein rings
Comparison
Before development of CHF vs after development of severe pacing-induced CHF
Design
Preclinical experimental study
Authors
Discussion
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Implication
Enhanced alpha1-responsiveness in experimental CHF; hypothesis-generating for vascular tone in human HF, prospective studies required.
Structured PICO
P
Population
Canine dorsal pedal arterial and saphenous vein rings from a dog model of severe pacing-induced heart failure
I
Intervention
Severe pacing-induced heart failure (CHF)
C
Comparator
Before development of CHF (baseline control)
O
Outcome
Postjunctional alpha-adrenoceptor characteristics (responsiveness and sensitivity to alpha-agonists and antagonists)surrogate
In a canine model of pacing-induced heart failure, the peripheral vasculature demonstrates increased reactivity and sensitivity to alpha 1-agonists.
Cite This Study
Forster et al. (1990) studied Pacing-induced heart failure. Pacing-induced heart failure vs. Before development of heart failure (control) was evaluated on Responsiveness and sensitivity of blood vessels to alpha-agonists. Pacing-induced heart failure in dogs significantly increased the reactivity and sensitivity of the peripheral vasculature to alpha 1-agonists compared with control.