Both alpha1- and alpha2-adrenoceptor-mediated contractile responses are increased in skeletal muscle resistance arteries from ischemic regions in patients with critical limb ischemia, potentially aggravating decreased blood flow.
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May worsen perfusion in ischemic limbs; leaves open whether alpha-adrenoceptor targeting improves outcomes in critical limb ischemia.
Yagna Jarajapu (2001) studied this question.
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