Why the study?
How do various α- and β-adrenoceptor agonists and antagonists affect heart rate and blood pressure in patients with chronic autonomic failure?
Population
7 patients with severe orthostatic hypotension due to peripheral autonomic neuropathy
Design
Case_series
Authors
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Case report data suggest differential adrenoceptor desensitization in autonomic failure; hypothesis-generating and should not change practice.
How do various α- and β-adrenoceptor agonists and antagonists affect heart rate and blood pressure in patients with chronic autonomic failure?
The study provides in vivo evidence for cardiac chronotropic β2-adrenoceptors in humans and suggests that α1-β1 and α2-β2 adrenoceptor sensitivity are independently regulated in chronic autonomic failure.
VELD et al. (1983) studied this question.
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