Preferential Desensitization to Cardiovascular β2-Adrenoceptor Stimulation in Patients with Peripheral Autonomic Neuropathy after Treatment with Pindolol

3 patients with orthostatic hypotension due to peripheral autonomic neuropathy (diagnosis based on severe hypotension during 60° head-up tilting and absence of systolic pressure overshoot in phase IV of Valsalva response, with no clinical evidence for central nervous system involvement).

Pindolol 15 mg daily, divided in three doses, for 4 weeks.

Baseline (pre-treatment) cardiovascular responses to infusions of isoprenaline, salbutamol, and prenalterol.

Shift in dose-heart rate response curves for isoprenaline, salbutamol, and prenalterol after 4 weeks of pindolol treatment.surrogate