Why the study?
Does pindolol reverse beta-adrenoceptor sensitization in patients with chronic autonomic failure?
Population
2 patients with orthostatic hypotension due to peripheral autonomic neuropathy with combined efferent…
Comparison
Pindolol 15 mg daily divided in three doses for… vs Baseline.
Design
Case_series
Follow-up
4 weeks
Authors
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Pindolol may reverse beta2 sensitization in autonomic failure; leaves open confirmation of cardiac beta2 function in controlled trials.
Does pindolol reverse beta-adrenoceptor sensitization in patients with chronic autonomic failure?
Pindolol treatment reverses preferential beta 2-adrenoceptor sensitization in patients with chronic autonomic failure, providing evidence for functional cardiac beta 2-adrenoceptors in humans.
Veld et al. (1982) studied this question.
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