June 1, 1989Cardiovascular Research
Vascular smooth muscle responsiveness to noradrenaline and phenylephrine following experimental heart failure in dogs
Key result
Severe CHF increases vascular smooth muscle sensitivity and maximal tension to adrenergic agents.
Why the study?
Adrenergic vascular responsiveness changes following the development of congestive heart failure in dogs were assessed to understand alterations in vascular smooth muscle sensitivity.
Does experimental heart failure alter vascular smooth muscle responsiveness to noradrenaline and phenylephrine in dogs?
Population
Dogs before and after development of experimental congestive heart failure
Comparison
Adrenergic responsiveness before versus after CHF development
Design
Preclinical experimental study
Authors
Discussion
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Implication
Enhanced vascular adrenergic responsiveness in experimental CHF; leaves open human relevance and mechanisms.
Structured PICO
Does experimental heart failure alter vascular smooth muscle responsiveness to noradrenaline and phenylephrine in dogs?
P
Population
Dogs assessed for adrenergic vascular responsiveness before and after the development of experimental congestive heart failure.
E
Exposure
Noradrenaline, phenylephrine, and prazosin
C
Comparator
Baseline (before the development of CHF)
O
Outcome
Adrenergic vascular responsiveness (maximum tension and concentration-effect curve) in the dorsal pedal artery and saphenous veinsurrogate
Experimental heart failure in dogs increases vascular smooth muscle sensitivity to adrenergic agents, potentially due to an increased proportion of alpha-1 adrenoceptors.
Cite This Study
Forster et al. (1989) studied Congestive heart failure. Development of congestive heart failure vs. Before development of congestive heart failure was evaluated on Adrenergic vascular responsiveness (maximum tension and concentration-effect curve). Following the development of severe congestive heart failure in dogs, vascular smooth muscle showed increased sensitivity to adrenergic agents, producing greater maximum tension.