August 1, 1999Acta Physiologica Scandinavica

Decreased responsiveness of vascular postjunctional α₁‐, α₂‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure

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Population

60 Sprague-Dawley rats

Comparison

Preganglionic sympathetic nerve stimulation and… vs Sham operated rats

Design

Preclinical

Follow-up

2 months post-surgery

Authors

QFQingping FengWestern University XSXingshu SunPurdue University West Lafayette XLXiangru LuAnhui Polytechnic University

Discussion

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Implication

Reduced vascular reactivity in rat HF is hypothesis-generating; leaves open translation to human receptor function or therapy.

Structured PICO

Population

60 Sprague-Dawley rats (n=30 with heart failure induced by coronary artery ligation, n=30 sham-operated controls)

Intervention

Preganglionic sympathetic nerve stimulation (PNS) and administration of alpha1-adrenoceptor agonist (phenylephrine), alpha2-adrenoceptor agonists (clonidine, BHT933), and neuropeptide Y (NPY)

Comparator

Sham operated rats

Outcome

Mean arterial pressure (MAP) response to preganglionic sympathetic nerve stimulation and receptor agonistssurrogate

Chronic heart failure in rats leads to decreased vascular responsiveness to postjunctional alpha1- and alpha2-adrenoceptors and neuropeptide Y1 receptors.

Cite This Study

Feng et al. (1999) studied this question.

synapsesocial.com/papers/6a7a2d12fbd9051d3b0e2604 https://doi.org/10.1046/j.1365-201x.1999.00570.x

Topics

Heart failure HFrEF treatment

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Decreased responsiveness of vascular postjunctional α₁‐, α₂‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Decreased responsiveness of vascular postjunctional α₁‐, α₂‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

Also Consider