Why the study?
Does experimental heart failure impair peripheral sympathetic vasoconstriction in response to lumbar chain stimulation in dogs?
Population
Normal dogs and dogs with chronic heart failure produced by rapid ventricular pacing
Comparison
Lumbar chain stimulation and norepinephrine… vs Normal dogs
Design
Preclinical
Authors
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Impaired sympathetic vasoconstriction in experimental HF suggests presynaptic defects; leaves open relevance to human compensatory mechanisms.
Does experimental heart failure impair peripheral sympathetic vasoconstriction in response to lumbar chain stimulation in dogs?
Experimental chronic heart failure impairs sympathetic vasoconstriction at higher stimulation frequencies, likely due to reduced neurotransmitter release, which may compromise compensatory mechanisms.
Wilson et al. (1988) studied this question.
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