Key result
Naloxone infusion significantly attenuated the development of hypertension in two-kidney one-clip Goldblatt rats compared to saline (SBP 132 vs 160 mmHg at day 14).
Why the study?
Does naloxone attenuate the development of hypertension in two-kidney one-clip Goldblatt rats?
Population
Male Sprague-Dawley rats with two-kidney one-clip Goldblatt hypertension (left renal artery constriction)
Comparison
Intraperitoneal infusion of naloxone via osmotic… vs Intraperitoneal infusion of saline via osmotic…
Design
Preclinical
Follow-up
14 days
Authors
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Should not change clinical hypertension management; leaves open opioid system involvement in renovascular hypertension pathogenesis.
Does naloxone attenuate the development of hypertension in two-kidney one-clip Goldblatt rats?
Absolute Event Rate: 132% vs 160%
Naloxone significantly attenuates the development of renovascular hypertension in a rat model, suggesting the endogenous opioid system may be involved in its pathogenesis.
Chen et al. (1988) studied Renovascular hypertension. Naloxone vs. Saline was evaluated on Systolic blood pressure (SBP) at day 14. Naloxone infusion significantly attenuated the development of hypertension in two-kidney one-clip Goldblatt rats compared to saline (SBP 132 vs 160 mmHg at day 14).
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