Why the study?
Does L-NAME supplementation alter the blood pressure and renal function responses to surgical unclipping in 1K1C Goldblatt hypertensive rats?
Does L-NAME supplementation alter the blood pressure and renal function responses to surgical unclipping in 1K1C Goldblatt hypertensive rats?
Nitric oxide production partly contributes to the hypotensive and renal responses to unclipping but does not mediate the complete reversal of renovascular hypertension in the 1K1C rat model.
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NO partly mediates post-unclipping BP and renal responses in 1K1C rats; leaves open full reversal mechanisms and human translation.
Huang et al. (1998) studied this question.
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