Why the study?
Does nitric oxide synthase inhibition with L-NAME alter carotid artery distensibility in renal hypertensive rats?
Population
Eight-week old male Wistar rats, n=102 (53 two-kidney, one clip [2K1C] Goldblatt rats, 49 sham operation)
Comparison
NG-nitro-L-arginine methyl ester in drinking… vs Water (vehicle) for 2 weeks
Design
Preclinical
Follow-up
2 weeks
Authors
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Hypothesis-generating for NO-independent mechanisms in renovascular arterial hypertrophy; leaves open translation to human hypertension.
Does nitric oxide synthase inhibition with L-NAME alter carotid artery distensibility in renal hypertensive rats?
Artery wall hypertrophy in renovascular hypertension is accompanied by an increase in arterial distensibility that is independent of nitric oxide synthesis.
Delacrétaz et al. (1995) studied this question.
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