Population
40 rats: 12-week-old Wistar-Kyoto rats (n=26) and age-matched spontaneously hypertensive rats (SHR, n=14)
Comparison
NG-nitro-L-arginine-methyl ester 0.4 g/L in… vs Tap water for 6 weeks
Design
Preclinical
Follow-up
6 weeks
Authors
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NOS inhibition yields hypertension without enhanced distensibility in rats; leaves open nitric oxide's role in human arterial mechanics.
Long-term nitric oxide synthase inhibition causes hypertension and arterial hypertrophy without the increased arterial distensibility seen in spontaneously hypertensive rats, suggesting nitric oxide regulates arterial mechanical behavior.
Delacrétaz et al. (1994) studied this question.
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