Why the study?
Does chronic inhibition of nitric oxide synthesis cause coronary microvascular remodeling and cardiac hypertrophy in Wistar-Kyoto rats?
Population
Wistar-Kyoto rats
Comparison
L-NAME 1 g/L, L-NAME 0.1 g/L, or L-NAME 1.0 g/L… vs No treatment
Design
Preclinical
Follow-up
8 weeks
Authors
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Supports direct NO effects on remodeling beyond hypertension in rats; hypothesis-generating for human microvascular disease.
Does chronic inhibition of nitric oxide synthesis cause coronary microvascular remodeling and cardiac hypertrophy in Wistar-Kyoto rats?
Long-term blockade of nitric oxide synthesis causes coronary microvascular remodeling and cardiac hypertrophy in rats independent of arterial hypertension.
Numaguchi et al. (1995) studied this question.
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