Population
Conscious rabbits (including sinoaortic-denervated rabbits)
Comparison
Intravenous naloxone pretreatment followed by… vs No pretreatment before intracerebroventricular…
Design
Preclinical
Authors
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Naloxone's central attenuation of baroreflex sensitivity may alter autonomic responses to endothelin-1; leaves open translation to human cardiovascular regulation.
Intravenous naloxone acts in the central nervous system to attenuate baroreflex sensitivity, augmenting the sympathetic and pressor responses to central endothelin-1 in conscious rabbits.
Matsumura et al. (1994) studied this question.
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