Key result
Naloxone augmented the increase in muscle sympathetic nerve activity during isometric handgrip compared to control trials (30 vs. 16 arbitrary units; P<0.05).
Why the study?
Does naloxone augment muscle sympathetic nerve activity during isometric exercise in young volunteers?
Population
19 young male and female volunteers
Comparison
Naloxone 1.2 mg IV bolus vs Placebo saline
Design
Other
Authors
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Naloxone may enhance sympathetic activation during isometric exercise in healthy adults; leaves open opioid modulation of autonomic control in disease.
RCT (n=19)
Does naloxone augment muscle sympathetic nerve activity during isometric exercise in young volunteers?
Absolute Event Rate: 30% vs 16%
p-value: p=<0.05
Naloxone augments muscle sympathetic nerve activity and arterial blood pressure during isometric handgrip exercise, suggesting endogenous opioid peptides modify sympathetic neural responses to muscle contraction.
Farrell et al. (1991) conducted an RCT in Healthy volunteers (n=19). Naloxone vs. Placebo saline was evaluated on Increase in muscle sympathetic nerve activity (MSNA) during isometric handgrip (p=<0.05). Naloxone augmented the increase in muscle sympathetic nerve activity during isometric handgrip compared to control trials (30 vs. 16 arbitrary units; P<0.05).
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