November 1, 2002Journal of Applied Physiology
Effect of morphine on sympathetic nerve activity in humans
Why the study?
Does morphine modulate sympathetic and cardiovascular responses at rest and during isometric exercise in humans?
Population
11 human subjects
Comparison
Systemic infusion of morphine vs Placebo (saline)
Design
RCT, double-blinded
Authors
Discussion
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Member takes
Implication
Morphine augments resting sympathetic activity and MAP; extends evidence by showing preserved responses to isometric exercise.
Structured PICO
Does morphine modulate sympathetic and cardiovascular responses at rest and during isometric exercise in humans?
P
Population
11 human subjects
I
Intervention
Systemic infusion of morphine (0.075 mg/kg loading dose + 1 mg/h maintenance)
C
Comparator
Placebo (saline)
O
Outcome
Muscle sympathetic nerve activity (MSNA), mean arterial pressure (MAP), and heart rate (HR) at rest, during isometric handgrip (IHG), and during postexercise muscle ischemia (PEMI)surrogate
Morphine alters resting sympathetic nerve activity and hemodynamics but does not affect the sympathetic response to isometric exercise.
Cite This Study
Carter et al. (2002) studied this question.