Why the study?
Does opioid modulation with codeine or naltrexone alter forearm muscle pain, exertion, or muscle sympathetic nerve activity during fatiguing exercise in healthy men?
Population
12 college-age men, mean age 24 +/- 4 years
Comparison
60 mg codeine or 50 mg naltrexone ingested 1… vs Placebo
Follow-up
Acute (during exercise and recovery)
Authors
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Null findings in healthy men do not support opioid modulation for exercise pain or MSNA; leaves open effects in clinical populations.
Does opioid modulation with codeine or naltrexone alter forearm muscle pain, exertion, or muscle sympathetic nerve activity during fatiguing exercise in healthy men?
Modulation of the endogenous opioid system with codeine or naltrexone does not significantly alter muscle pain perception, exertion, or sympathetic nerve activity during high-intensity fatiguing exercise.
Cook et al. (2000) studied this question.
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