Key result
Morphine (0.2 mg/kg) significantly reduced ventilatory responses to carbon dioxide and hypoxia to one-half and one-third of control, respectively, but did not alter the relationship between ventilation and metabolic rate during steady-state exercise.
Why the study?
Does morphine 0.2 mg/kg alter the ventilatory response to exercise in normal subjects?
Population
6 normal subjects
Comparison
Morphine 0.2 mg/kg vs Control (pre-drug state)
Design
Other
Authors
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Caution against extrapolating to patients; leaves open effects on exercise tolerance in cardiopulmonary disease.
Does morphine 0.2 mg/kg alter the ventilatory response to exercise in normal subjects?
Morphine blunts chemoreception for hypoxia and hypercapnia and reduces ventilatory responses during exercise, but does not alter the relationship between ventilation and metabolic rate during steady-state exercise.
Santiago et al. (1979) studied Healthy (n=6). Morphine vs. Control (baseline) was evaluated on Ventilatory response to exercise, carbon dioxide, and hypoxia. Morphine (0.2 mg/kg) significantly reduced ventilatory responses to carbon dioxide and hypoxia to one-half and one-third of control, respectively, but did not alter the relationship between ventilation and metabolic rate during steady-state exercise.
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