Key result
Morphine administration in conscious rats resulted in substantially smaller increases in minute ventilation during a subsequent hypoxic challenge, even after initial morphine-induced respiratory depression had resolved.
Why the study?
Does morphine depress ventilatory responses to a hypoxic challenge in conscious rats after acute effects have subsided?
Population
Adult male Sprague-Dawley rats (n=56 total across experiments), conscious and unrestrained.
Comparison
Morphine followed by hypoxic challenge vs Vehicle followed by hypoxic challenge
Design
Preclinical
Follow-up
Up to 90 minutes for analgesia, 30 minutes for ABG, 3…
Authors
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Hypothesis-generating in rats; suggests latent morphine effects on hypoxic ventilation but should not yet alter clinical practice.
Does morphine depress ventilatory responses to a hypoxic challenge in conscious rats after acute effects have subsided?
p-value: p=<0.05
Morphine has latent deleterious effects on ventilatory responses to hypoxic challenges even after acute respiratory depressant effects have resolved.
May et al. (2013) studied Healthy (animal model) (n=56). Morphine vs. Vehicle (saline) was evaluated on Minute ventilation (Vm) response to first hypoxic challenge (p=<0.05). Morphine administration in conscious rats resulted in substantially smaller increases in minute ventilation during a subsequent hypoxic challenge, even after initial morphine-induced respiratory depression had resolved.
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