What question did this study set out to answer?

To determine whether morphine-induced respiratory depression is driven by altered ventilatory responsiveness to hypoxia and hypercapnia.

May 22, 1975New England Journal of Medicine

Diminished Ventilatory Response to Hypoxia and Hypercapnia after Morphine in Normal Man

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Authors

JWJohn V. WeilWebb Institute RMRobert E. McCulloughUniversity of Utah JKJeffrey KlineIndiana University School of Medicine

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Implication

Interventional study demonstrates reduced ventilatory response to hypoxia and hypercapnia after subcutaneous morphine in healthy humans, suggesting blunted chemoreflexes drive respiratory depression.

Key Points

To determine whether morphine-induced respiratory depression is driven by altered ventilatory responsiveness to hypoxia and hypercapnia.
Measured ventilatory responses to hypoxia and hypercapnia before and after subcutaneous administration of 7.5 mg morphine sulfate in six healthy subjects.
Assessed resting alveolar carbon dioxide tension, hypoxic ventilatory drive (parameter A), and hypercapnic ventilatory drive slope at serial time points up to 75 minutes post-injection.
Resting alveolar carbon dioxide tension increased from 42.9 ± 1.7 to 45.4 ± 1.5 mm Hg at 30 minutes post-morphine (p > 0.01).
Hypoxic ventilatory drive (parameter A) decreased from 108 ± 17.6 to 42.8 ± 5.3 at 60 minutes after morphine (p > 0.01).
Hypercapnic ventilatory drive slope decreased from 1.69 ± 0.24 to 0.98 ± 0.20 at 75 minutes after morphine (p > 0.01).

Cite This Study

Weil et al. (1975) studied this question.

synapsesocial.com/papers/69d18cca360df9e887456ff9 https://doi.org/10.1056/nejm197505222922106

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Implication

Interventional study demonstrates reduced ventilatory response to hypoxia and hypercapnia after subcutaneous morphine in healthy humans, suggesting blunted chemoreflexes drive respiratory depression.

Diminished Ventilatory Response to Hypoxia and Hypercapnia after Morphine in Normal Man

Discussion

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Implication

Key Points

Cite This Study

Diminished Ventilatory Response to Hypoxia and Hypercapnia after Morphine in Normal Man

Discussion

Member takes

Implication

Key Points

Cite This Study

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