Why the study?
Does intravenous naloxone increase ventilatory response to hypercapnic hypoxia in healthy adults?
Population
28 healthy adults (n=21 in naloxone group, n=7 in control group)
Comparison
Intravenous infusion of 3 mg of naloxone vs Normal saline
Design
Other
Authors
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Naloxone may modulate hypoxic ventilatory drive; leaves open clinical relevance in patients with respiratory disorders.
Does intravenous naloxone increase ventilatory response to hypercapnic hypoxia in healthy adults?
Endogenous opioids participate in the central control of breathing during hypercapnic hypoxia in normal adults, as evidenced by increased ventilatory response following naloxone administration.
Akiyama et al. (1990) studied this question.
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