Key result
Intravenous naloxone fails to alter MAP, HR, or plasma catecholamines in normotensive or hypertensive humans.
Why the study?
Does intravenous naloxone alter mean arterial pressure, heart rate, or plasma catecholamine levels in normotensive or hypertensive humans?
Population
23 individuals including 12 surgical patients receiving nitrous oxide, oxygen, and halothane anesthesia and…
Comparison
Intravenous naloxone, 0.2 mg followed 30 minutes… vs Baseline values before intravenous naloxone…
Design
Other
Authors
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May support low-dose naloxone use without hemodynamic concerns in normotensive or hypertensive patients; leaves open confirmation in larger trials.
Does intravenous naloxone alter mean arterial pressure, heart rate, or plasma catecholamine levels in normotensive or hypertensive humans?
p-value: p=not statistically significant
Intravenous naloxone does not significantly alter hemodynamics or plasma catecholamine levels in normotensive or hypertensive individuals, whether anesthetized or awake.
Estilo et al. (1982) studied Normotensive and hypertensive surgical patients and volunteers (n=23). Naloxone vs. Baseline (before intravenous naloxone) was evaluated on Changes in mean arterial pressure, heart rate, plasma norepinephrine, epinephrine, and dopamine levels (p=not statistically significant). Intravenous naloxone administration (0.2 mg and 0.4 mg) did not significantly alter mean arterial pressure, heart rate, or plasma catecholamine levels in normotensive or hypertensive humans.
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