Contribution of vagal afferents to respiratory reflexes evoked by acute inhalation of ozone in dogs

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Why the study?

Does afferent vagal C-fiber blockade prevent ozone-induced respiratory reflexes in anesthetized dogs?

Structured PICO

Does afferent vagal C-fiber blockade prevent ozone-induced respiratory reflexes in anesthetized dogs?

Population

Spontaneously breathing anesthetized dogs

Intervention

Inhalation of 3 ppm ozone for 40-70 min into the lower trachea with cervical vagal temperature maintained successively at 37, 7, and 0 degrees C

Comparator

Air breathing at corresponding temperatures

Outcome

Respiratory reflexes (tidal volume, dynamic lung compliance, breathing frequency, total lung resistance, and tracheal smooth muscle tension)surrogate

Afferent vagal C-fibers in the lower airways play a major role in mediating the acute respiratory effects of ozone inhalation in dogs.

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Vagal C-fiber blockade attenuates ozone reflexes in dogs; leaves open translation to human pollution responses.

Schelegle et al. (1993) studied this question.

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