Why the study?
Does the state of oxygenation (hypoxia or hyperoxia) alter histamine-induced reflex tracheal constriction in dogs?
Population
Anesthetized, paralyzed, and artificially ventilated dogs
Comparison
Aerosolized histamine challenge during hypoxic… vs Aerosolized histamine challenge during normoxia
Design
Preclinical
Authors
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Supports vagal reflex modulation by oxygenation in dogs; leaves open translation to human airway disease.
Does the state of oxygenation (hypoxia or hyperoxia) alter histamine-induced reflex tracheal constriction in dogs?
The prevailing state of oxygenation modulates vagal reflex bronchomotor tone, with hypoxia potentiating and hyperoxia attenuating histamine-induced tracheal constriction.
Vidruk et al. (1985) studied this question.