Key result
Inhalation of 5 or 10% oxygen in anesthetized dogs increased pulmonary arterial pressure and blood flow, with reflex vasoconstriction activated by a ≥10% reduction in arterial oxygen saturation.
Population
Anesthetized dogs
Design
Preclinical
Authors
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May activate hypoxic pulmonary vasoconstriction earlier than local mechanisms in dogs; leaves open human translation and clinical relevance.
Anoxia induces reflex pulmonary vasoconstriction mediated by thoracic sympathetics in anesthetized dogs, which is activated by milder anoxemia compared to local and passive dilatory mechanisms.
Aviado et al. (1957) studied Anoxia in anesthetized dogs. Inhalation of 5 or 10% oxygen was evaluated on Pulmonary arterial pressure, pulmonary blood flow, and pulmonary vascular resistance. Inhalation of 5 or 10% oxygen in anesthetized dogs increased pulmonary arterial pressure and blood flow, with reflex vasoconstriction activated by a ≥10% reduction in arterial oxygen saturation.
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