Randomized trial uncovers metabolic reprogramming's role in T cell exhaustion, suggesting implications for boosting antitumor immunity.
Metabolic reprogramming of T lymphocytes has a decisive role in their activation, differentiation, and functional fate commitment. Metabolic reprogramming guides not only the generation of T effector and T memory cells but also the development of dysfunctional exhausted (T EX ) cells. A recent study by Haku et al published in Nature Immunology provides new insights into the role of mitochondria in regulating the metabolic capabilities of T EX cells and their implications for antitumor immunity.
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Aliazis et al. (2026) studied this question.
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