PURPOSE: Taxane-induced peripheral neuropathy (TIPN) is a common, dose-limiting, and often irreversible toxicity that profoundly diminishes patients' long-term quality of life and compromises taxane treatment efficacy. This study aimed to identify and replicate plasma lipidomic biomarkers of TIPN and paclitaxel pharmacokinetics (PK). METHODS: ). Plasma lipidomics were quantified using the end-of-infusion sample. Linear mixed-effects and linear regression models were used to identify lipids associated with TIPN severity and paclitaxel PK, respectively, with a prespecified false discovery rate of 0.05. RESULTS: . CONCLUSION: . Larger prospective studies are needed to validate these findings and inform the development of lipid-guided personalized treatment strategies that mitigate TIPN and improve long-term outcomes.
Liu et al. (Wed,) studied this question.